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As mentioned previously, drug discovery is a complex and risky treasure
hunt to find the most efficacious molecule which do not have toxic effects
but at the same time have desired pharmacokinetic profile. The hunt starts
when the researchers look for the binding affinity of the molecule to its
target. Huge amount of research requires to be done to come out with a
molecule which has the reliable binding profile. Once the molecules have
been identified, as per the traditional methodologies, the molecule is
further subjected to optimization with the aim of improving efficacy. The
molecules which show better binding is then evaluated for its toxicity and
pharmacokinetic profiles. It is at this stage that most of the candidates
fail in the race to become a successful drug.
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Last Update June 2005 |